EXETER City will host Peterborough United in the Round Two of the Checkatrade Trophy.
Bristol Rovers, meanwhile, will travel to Swansea City Under-21.
The draw was made on Friday afternoon by former winners of the competition Leon Britton and Steve Claridge.
Ties will be played week commencing 3 December.
Confirmed Round Two ties are as follows:
|Accrington Stanley||V||Lincoln City|
|Newcastle United U21||V||Macclesfield Town|
|Port Vale||V||Stoke City U21|
|Barnsley||V||Manchester City U21|
|Chelsea U21||V||AFC Wimbledon|
|Cambridge United||V||Northampton Town|
|Exeter City||V||Peterborough United|
|Cheltenham Town||V||Newport County|
|Luton Town||V||Southend United|
|Oxford United||V||Tottenham Hotspur U21|
|Swansea City U21||V||Bristol Rovers|